| Mellor, Paul; Marshall, Jeremy D. S.; Ruan, Xuan; Whitecross, Dielle E.; Ross, Rebecca L. et al. (2018). Patient-derived mutations within the N-terminal domains of p85α impact PTEN or Rab5 binding and regulation. Scientific Reports 8(1) . 10.1038/s41598-018-25487-5. [PDB: 6d81, 6d82, 6d85, 6d86, 6d87] |
CMCF-BM, CMCF-ID |
Peer-Reviewed Article |
Health |
| Bonday, Zahid Q.; Cortez, Guillermo S.; Grogan, Michael J.; Antonysamy, Stephen; Weichert, Ken et al. (2018). LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity. ACS Medicinal Chemistry Letters 9(7) , 612-617. 10.1021/acsmedchemlett.8b00014. [PDB: 6ckc] |
CMCF-ID |
Peer-Reviewed Article |
Health |
| Huang, Christine S.; Oberbeck, Nina; Hsiao, Yi-Chun; Liu, Peter; Johnson, Adam R. et al. (2018). Crystal Structure of Ripk4 Reveals Dimerization-Dependent Kinase Activity. Structure 26(5) , 767-777.e5. 10.1016/j.str.2018.04.002. [PDB: 5wni] |
CMCF-ID |
Peer-Reviewed Article |
Health |
| Bagal, Sharan K.; Omoto, Kiyoyuki; Blakemore, David C.; Bungay, Peter J.; Bilsland, James G. et al. (2018). Discovery of Allosteric, Potent, Subtype Selective, and Peripherally Restricted TrkA Kinase Inhibitors. Journal of Medicinal Chemistry 62(1) , 247-265. 10.1021/acs.jmedchem.8b00280. [PDB: 6d20] |
CMCF-ID |
Peer-Reviewed Article |
Health |
| Gebai, Ahmad; Gorelik, Alexei; Li, Zixian; Illes, Katalin; Nagar, Bhushan et al. (2018). Structural basis for the activation of acid ceramidase. Nature Communications 9(1) . 10.1038/s41467-018-03844-2. [PDB: 5u7z, 5u81, 5u84] |
CMCF-BM, CMCF-ID |
Peer-Reviewed Article |
Health |
| Jacques, Benoit; Coinçon, Mathieu; Sygusch, Jurgen (2018). Active site remodeling during the catalytic cycle in metal-dependent fructose-1,6-bisphosphate aldolases. Journal of Biological Chemistry 293(20) , 7737-7753. 10.1074/jbc.ra117.001098. [PDB: 5ucn, 5ucp, 5ucs, 5ucz, 5ud0, 5ud1, 5ud2] |
CMCF-BM, CMCF-ID |
Peer-Reviewed Article |
Health |
| Baral, Pravas Kumar; Swayampakula, Mridula; Aguzzi, Adriano; James, Michael N. G. (2018). Structural characterization of
POM
6 Fab and mouse prion protein complex identifies key regions for prions conformational conversion. FEBS Journal 285(9) , 1701-1714. 10.1111/febs.14438. [PDB: 6aq7] |
CMCF-BM |
Peer-Reviewed Article |
Health |
| Joan Seoane Suarez; Judit Anido Folgueira; Johan Fransson; Jean-Philippe Julien; Swetha RAMAN et al. (2018). Antibodies against lif and uses thereof. Patent Number: US20180169233A1. |
CMCF-ID |
Patent |
Health |
| Gajiwala, K.S.; Johnson, E.; Cronin, C.N. (2018). Structure of the PTK6 kinase domain. Protein Data Bank: 6cz2. |
CMCF-ID |
PDB Deposition |
Health |
| Gajiwala, K.S.; Johnson, E.; Cronin, C.N. (2018). Structure of the PTK6 kinase domain bound to a type I inhibitor (3-fluoro-4-{[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino}phenyl)(morpholin-4-yl)methanone. Protein Data Bank: 6cz3. |
CMCF-ID |
PDB Deposition |
Health |
| Scally, S.W.; Bosch, A.; Imkeller, K.; Wardemann, H.; Julien, J.P. et al. (2018). Crystal structure of 1450 Fab in complex with circumsporozoite protein NANP5. Protein Data Bank: 6d11. |
CMCF-ID |
PDB Deposition |
Health |
| Scally, S.W.; Bosch, A.; Imkeller, K.; Wardemann, H.; Julien, J.P. et al. (2018). Crystal structure of 1210 Fab in complex with circumsporozoite protein NANP5. Protein Data Bank: 6d01. |
CMCF-ID |
PDB Deposition |
Health |
| Alexander, J.A.N.; Strynadka, N.C.J. (2018). Crystal structure of wild-type S. aureus penicillin binding protein 4 (PBP4) in complex with nafcillin. Protein Data Bank: 5ty7. |
CMCF-ID |
PDB Deposition |
Health |
| Alexander, J.A.N.; Strynadka, N.C.J. (2018). Crystal structure of S. aureus penicillin binding protein 4 (PBP4) mutant (E183A, F241R) in complex with nafcillin. Protein Data Bank: 5ty2. |
CMCF-BM |
PDB Deposition |
Health |
| Fox III, D.; Lukacs, C.M. (2018). Crystal structure of FcRn bound to UCB-84. Protein Data Bank: 6c98. |
CMCF-ID |
PDB Deposition |
Health |