| Cottrell, Kevin M.; Briggs, Kimberly J.; Whittington, Douglas A.; Jahic, Haris; Ali, Janid A. et al. (2024). Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with MTAP-Deleted Cancers. Journal of Medicinal Chemistry 67(8) , 6064-6080. 10.1021/acs.jmedchem.4c00133. [PDB: 8veu] |
CMCF-ID |
Peer-Reviewed Article |
Health |
| Li, Franco K. K.; Worrall, Liam J.; Gale, Robert T.; Brown, Eric D.; Strynadka, Natalie C. J. et al. (2024). Cryo-EM analysis of
S. aureus
TarL, a polymerase in wall teichoic acid biogenesis central to virulence and antibiotic resistance. Science advances 10(9) . 10.1126/sciadv.adj3864. [PDB: 8v33] |
CMCF-ID |
Peer-Reviewed Article |
Health |
| Ketcham, John M.; Harwood, Stephen J.; Aranda, Ruth; Aloiau, Athenea N.; Bobek, Briana M. et al. (2024). Discovery of Pyridopyrimidinones that Selectively Inhibit the H1047R PI3Kα Mutant Protein. Journal of Medicinal Chemistry . 10.1021/acs.jmedchem.4c00078. [PDB: 8v8h] |
CMCF-ID |
Peer-Reviewed Article |
Health |
| Puumala, Emily; Sychantha, David; Lach, Elizabeth; Reeves, Shawn; Nabeela, Sunna et al. (2024). Allosteric inhibition of tRNA synthetase Gln4 by N-pyrimidinyl-β-thiophenylacrylamides exerts highly selective antifungal activity. Cell Chemical Biology . 10.1016/j.chembiol.2024.01.010. [PDB: 8uk6] |
CMCF-ID |
Peer-Reviewed Article |
Health |
| Folger, Ines B.; Frota, Natália F.; Pistofidis, Angelos; Niquille, David L.; Hansen, Douglas A. et al. (2024). High-throughput reprogramming of an NRPS condensation domain. Nature Chemical Biology . 10.1038/s41589-023-01532-x. [PDB: 8f7f] |
CMCF-ID |
Peer-Reviewed Article |
Health |
| Daniel-Ivad, Phillip; Ryan, Katherine S. (2024). An imine reductase that captures reactive intermediates in the biosynthesis of the indolocarbazole reductasporine. Journal of Biological Chemistry , 105642. 10.1016/j.jbc.2024.105642. |
CMCF-ID |
Peer-Reviewed Article |
Health |
| Edwards, M.M.; Dong, A.; Theo-Emegano, N.; Seitova, A.; Loppnau, P. et al. (2024). Chicken 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 (PLCZ1) in complex with calcium and phosphorylated threonine. Protein Data Bank: 9bcz. |
CMCF-ID |
PDB Deposition |
Health |
| kimani, S.; Dong, A.; Li, Y.; Seitova, A.; Al-Awar, R. et al. (2024). Crystal structure of the WDR domain of human DCAF1 in complex with OICR-40155 compound. Protein Data Bank: 9bhr. |
CMCF-ID |
PDB Deposition |
Health |
| Kozlov, G.; Gehring, K. (2024). Crystal structure of the complex between truncated MLLE domain of PABPC1 and engineered superPAM2 peptide. Protein Data Bank: 8smo. |
CMCF-ID |
PDB Deposition |
Health |
| Whittington, D.A. (2024). Crystal structure of PRMT5:MEP50 in complex with MTA and oxamide compound 23. Protein Data Bank: 8veu. |
CMCF-ID |
PDB Deposition |
Health |
| Saran, A.; Zeytuni, N. (2024). PorX phosphatase null mutant (T271V). Protein Data Bank: 8thp. |
CMCF-ID |
PDB Deposition |
Health |
| Saran, A.; Zeytuni, N. (2024). PorX with Zn (primitive orthorhombic crystal form). Protein Data Bank: 8tfm. |
CMCF-ID |
PDB Deposition |
Health |
| Xu, J.; Fu, Y.; Ding, X.; Meng, Q.; Wang, L. et al. (2024). co-crystal structure of non-carboxylic acid inhibitor with PHD2. Protein Data Bank: 8j1k. |
CMCF-ID |
PDB Deposition |
Health |
| Kozlov, G.; Jiang, J.; Gehring, K. (2024). LaM domain of human LARP1 in complex with Rp phosphorothioate isomer of AAAAA(SRA) RNA. Protein Data Bank: 8g91. |
CMCF-ID |
PDB Deposition |
Health |
| Kozlov, G.; Jiang, J.; Gehring, K. (2024). LaM domain of human LARP1 in complex with Sp phosphorothioate isomer of AAAAA(SRA) RNA. Protein Data Bank: 8g90. |
CMCF-ID |
PDB Deposition |
Health |