| Puumala, Emily; Sychantha, David; Lach, Elizabeth; Reeves, Shawn; Nabeela, Sunna et al. (2024). Allosteric inhibition of tRNA synthetase Gln4 by N-pyrimidinyl-β-thiophenylacrylamides exerts highly selective antifungal activity. Cell Chemical Biology . 10.1016/j.chembiol.2024.01.010. [PDB: 8uk6] |
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Peer-Reviewed Article |
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| Perez-Bermejo, Juan A.; Efagene, Oghene; Matern, William M.; Holden, Jeffrey K.; Kabir, Shaheen et al. (2024). Functional screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair. Nature Communications 15(1) . 10.1038/s41467-024-46816-5. [PDB: 8svg, 8svh, 8svi] |
CMCF-ID |
Peer-Reviewed Article |
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| Li, Franco K. K.; Worrall, Liam J.; Gale, Robert T.; Brown, Eric D.; Strynadka, Natalie C. J. et al. (2024). Cryo-EM analysis of
S. aureus
TarL, a polymerase in wall teichoic acid biogenesis central to virulence and antibiotic resistance. Science advances 10(9) . 10.1126/sciadv.adj3864. [PDB: 8v33] |
CMCF-ID |
Peer-Reviewed Article |
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| Ketcham, John M.; Harwood, Stephen J.; Aranda, Ruth; Aloiau, Athenea N.; Bobek, Briana M. et al. (2024). Discovery of Pyridopyrimidinones that Selectively Inhibit the H1047R PI3Kα Mutant Protein. Journal of Medicinal Chemistry . 10.1021/acs.jmedchem.4c00078. [PDB: 8v8h] |
CMCF-ID |
Peer-Reviewed Article |
Health |
| He, Liqi; Zhang, Meng Yao; Cox, Matthew; Zhang, Qian; Donnell, Andrew F. et al. (2024). Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology. ACS Medicinal Chemistry Letters 15(2) , 189-196. 10.1021/acsmedchemlett.3c00456. [PDB: 8s9h] |
CMCF-ID |
Peer-Reviewed Article |
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| Folger, Ines B.; Frota, Natália F.; Pistofidis, Angelos; Niquille, David L.; Hansen, Douglas A. et al. (2024). High-throughput reprogramming of an NRPS condensation domain. Nature Chemical Biology . 10.1038/s41589-023-01532-x. [PDB: 8f7f] |
CMCF-ID |
Peer-Reviewed Article |
Health |
| Daniel-Ivad, Phillip; Ryan, Katherine S. (2024). An imine reductase that captures reactive intermediates in the biosynthesis of the indolocarbazole reductasporine. Journal of Biological Chemistry , 105642. 10.1016/j.jbc.2024.105642. |
CMCF-ID |
Peer-Reviewed Article |
Health |
| Wang, F.; Cheng, W.; Yuan, Z.; Qi, J.; Shen, Z. et al. (2024). The Crystal Structure of SHP1 from Biortus.. Protein Data Bank: 8yhi. |
CMCF-ID |
PDB Deposition |
Health |
| Wang, F.; Cheng, W.; Yuan, Z.; Qi, J.; Shen, Z. et al. (2024). The Crystal Structure of UCHL1 from Biortus.. Protein Data Bank: 8xi7. |
CMCF-ID |
PDB Deposition |
Health |
| Wang, F.; Cheng, W.; Yuan, Z.; Lin, D.; Wang, J. et al. (2024). The Crystal Structure of USP8 from Biortus.. Protein Data Bank: 8xpn. |
CMCF-ID |
PDB Deposition |
Health |
| Wang, F.; Cheng, W.; Yuan, Z.; Lin, D.; Guo, S. et al. (2024). The Crystal Structure of MAPK11 from Biortus. Protein Data Bank: 8ygw. |
CMCF-ID |
PDB Deposition |
Health |
| Wang, F.; Cheng, W.; Yuan, Z.; Lin, D.; Bao, C. et al. (2024). The Crystal Structure of p53/BCL-xL fusion complex from Biortus.. Protein Data Bank: 8xp5. |
CMCF-ID |
PDB Deposition |
Health |
| Wang, F.; Cheng, W.; Yuan, Z.; Lin, D.; Bao, C. et al. (2024). Structure of the GFP:GFP-nanobody complex from Biortus.. Protein Data Bank: 8xld. |
CMCF-ID |
PDB Deposition |
Health |
| Wang, F.; Cheng, W.; Lv, Z.; Qi, J.; Wu, B. et al. (2024). The Crystal Structure of P21-Activated Kinases Pak4 from Biortus. Protein Data Bank: 8yhk. |
CMCF-ID |
PDB Deposition |
Health |
| Wang, F.; Cheng, W.; Lv, Z.; Qi, J.; Wu, B. et al. (2024). The Crystal Structure of Mitotic Kinesin Eg5 from Biortus. Protein Data Bank: 8yhh. |
CMCF-ID |
PDB Deposition |
Health |