Yang, Yuhong; Xu, Yuanyuan; Yue, Yuan; Wang, Heng; Cui, Yumeng et al. (2021). Investigate Natural Product Indolmycin and the Synthetically Improved Analogue Toward Antimycobacterial Agents. ACS Chemical Biology 17(1) , 39-53. 10.1021/acschembio.1c00394. |
CMCF-ID |
Peer-Reviewed Article |
Health |
Wrobleski, Stephen T.; Moslin, Ryan; Lin, Shuqun; Zhang, Yanlei; Spergel, Steven et al. (2019). Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165. Journal of Medicinal Chemistry 62(20) . 10.1021/acs.jmedchem.9b00444. |
CMCF-ID |
Peer-Reviewed Article |
Health |
Whitesell, Luke; Robbins, Nicole; Huang, David S.; McLellan, Catherine A.; Shekhar-Guturja, Tanvi et al. (2019). Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus. Nature Communications 10(1) , 402. 10.1038/s41467-018-08248-w. |
CMCF-ID |
Peer-Reviewed Article |
Health |
Wagner, Florence F.; Benajiba, Lina; Campbell, Arthur J.; Weïwer, Michel; Sacher, Joshua R. et al. (2018). Exploiting an Asp-Glu “switch” in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Science Translational Medicine 10(431) , eaam8460. 10.1126/scitranslmed.aam8460. |
CMCF-ID |
Peer-Reviewed Article |
Health |
Vuong, Wayne; Fischer, Conrad; Khan, Muhammad Bashir; van Belkum, Marco J.; Lamer, Tess et al. (2021). Improved SARS-CoV-2 Mpro inhibitors based on feline antiviral drug GC376: Structural enhancements, increased solubility, and micellar studies. European Journal of Medicinal Chemistry 222, 113584. 10.1016/j.ejmech.2021.113584. |
CMCF-BM |
Peer-Reviewed Article |
Health |
Von Dwingelo, Juanita; Chung, Ivy Yeuk Wah; Price, Christopher T.; Li, Lei; Jones, Snake et al. (2019). Interaction of the Ankyrin H Core Effector of
Legionella
with the Host LARP7 Component of the 7SK snRNP Complex. mBio 10(4) , e01942-19. 10.1128/mbio.01942-19. |
CMCF-BM, CMCF-ID |
Peer-Reviewed Article |
Health |
Velagapudi, Uday Kiran; Langelier, Marie-France; Delgado-Martin, Cristina; Diolaiti, Morgan E.; Bakker, Sietske et al. (2019). Design and Synthesis of Poly(ADP-ribose) Polymerase Inhibitors: Impact of Adenosine Pocket-Binding Motif Appendage to the 3-Oxo-2,3-dihydrobenzofuran-7-carboxamide on Potency and Selectivity. Journal of Medicinal Chemistry 62(11) , 5330-5357. 10.1021/acs.jmedchem.8b01709. |
CMCF-ID |
Peer-Reviewed Article |
Health |
Vatta, Maritza; Lyons, Bronwyn; Heney, Kayla A.; Lidster, Taylor; Merrill, A. Rod et al. (2021). Mapping the DNA-Binding Motif of Scabin Toxin, a Guanine Modifying Enzyme from Streptomyces scabies. Toxins 13(1) , 55. 10.3390/toxins13010055. |
CMCF-ID |
Peer-Reviewed Article |
Health |
Vance, Tyler D.R.; Ye, Qilu; Conroy, Brigid; Davies, Peter L. (2020). Essential role of calcium in extending RTX adhesins to their target. Journal of Structural Biology: X 4, 100036. 10.1016/j.yjsbx.2020.100036. |
CMCF-ID |
Peer-Reviewed Article |
Health |
Ulaganathan, ThirumalaiSelvi; Helbert, William; Kopel, Moran; Banin, Ehud; Cygler, Miroslaw et al. (2018). Structure–function analyses of a PL24 family ulvan lyase reveal key features and suggest its catalytic mechanism. Journal of Biological Chemistry 293(11) , 4026-4036. 10.1074/jbc.ra117.001642. |
CMCF-BM, CMCF-ID |
Peer-Reviewed Article |
Health |
Ulaganathan, ThirumalaiSelvi; Banin, Ehud; Helbert, William; Cygler, Miroslaw (2018). Structural and functional characterization of PL28 family ulvan lyase NLR48 from Nonlabens ulvanivorans. Journal of Biological Chemistry 293(29) , 11564-11573. 10.1074/jbc.ra118.003659. |
CMCF-BM, CMCF-ID |
Peer-Reviewed Article |
Health |
Tomasz Wysokinski; Denise Miller; Robert Blyth; Pawel Grochulski (2018). Life Science Programs at the Canadian Light Source: Overview Of The Bio-medical Studies At BMIT. . https://proceedings.cmbes.ca/index.php/proceedings/article/view/607/600. |
BMIT-BM, BMIT-ID |
Conference Proceeding |
Health |
Tarry, Michael J.; Harmel, Christoph; Taylor, James A.; Marczynski, Gregory T.; Schmeing, T. Martin et al. (2019). Structures of GapR reveal a central channel which could accommodate B-DNA. Scientific Reports 9(1) . 10.1038/s41598-019-52964-2. |
CMCF-ID |
Peer-Reviewed Article |
Health |
Stöppler, Daniel; Macpherson, Alex; Smith-Penzel, Susanne; Basse, Nicolas; Lecomte, Fabien et al. (2018). Insight into small molecule binding to the neonatal Fc receptor by X-ray crystallography and 100 kHz magic-angle-spinning NMR. PLoS Biology 16(5) , e2006192. 10.1371/journal.pbio.2006192. |
CMCF-ID |
Peer-Reviewed Article |
Health |
Stirling, Alexander J.; Gilbert, Stephanie E.; Conner, Megan; Mallette, Evan; Kimber, Matthew S. et al. (2020). A Key Glycine in Bacterial Steroid-Degrading Acyl-CoA Dehydrogenases Allows Flavin-Ring Repositioning and Modulates Substrate Side Chain Specificity. Biochemistry 59(42) , 4081-4092. 10.1021/acs.biochem.0c00568. |
CMCF-ID |
Peer-Reviewed Article |
Health |