Publication Beamlines Strategic Pillar
Baker, Perrin; Whitfield, Gregory B.; Hill, Preston J.; Little, Dustin J.; Pestrak, Matthew J. et al. (2015). Characterization of the Pseudomonas aeruginosa Glycoside Hydrolase PslG Reveals That Its Levels Are Critical for Psl Polysaccharide Biosynthesis and Biofilm Formation. Journal of Biological Chemistry 290(47) , 28374-28387. 10.1074/jbc.m115.674929. [PDB: 5bxa] CMCF-ID Health
Bamford, Natalie C.; Snarr, Brendan D.; Gravelat, Fabrice N.; Little, Dustin J.; Lee, Mark J. et al. (2015). Sph3 Is a Glycoside Hydrolase Required for the Biosynthesis of Galactosaminogalactan in Aspergillus fumigatus. Journal of Biological Chemistry 290(46) , 27438-27450. 10.1074/jbc.m115.679050. [PDB: 5d6t] CMCF-BM Health
Baral, Pravas Kumar; Swayampakula, Mridula; Aguzzi, Adriano; James, Michael N.G. (2015). X-ray structural and molecular dynamical studies of the globular domains of cow, deer, elk and Syrian hamster prion proteins. Journal of Structural Biology 192(1) , 37-47. 10.1016/j.jsb.2015.08.014. [PDB: 4yx2] CMCF-BM Health
Blackler, Ryan J; Evans, Dylan W; Smith, David F; Cummings, Richard D; Brooks, Cory L et al. (2015). Single-chain antibody-fragment M6P-1 possesses a mannose 6-phosphate monosaccharide-specific binding pocket that distinguishesN-glycan phosphorylation in a branch-specific manner. Glycobiology 26(2) , 181-192. 10.1093/glycob/cwv093. [PDB: 4rzc] CMCF-ID Health
Concha, Nestor O.; Smallwood, Angela; Bonnette, William; Totoritis, Rachel; Zhang, Guofeng et al. (2015). Long-Range Inhibitor-Induced Conformational Regulation of Human IRE1αEndoribonuclease Activity. Molecular Pharmacology 88(6) , 1011-1023. 10.1124/mol.115.100917. [PDB: 4yzd] CMCF-ID Health
Gregg, Katie J.; Suits, Michael D.L.; Deng, Lehua; Vocadlo, David J.; Boraston, Alisdair B. et al. (2015). Structural Analysis of a Family 101 Glycoside Hydrolase in Complex with Carbohydrates Reveals Insights into Its Mechanism. Journal of Biological Chemistry 290(42) , 25657-25669. 10.1074/jbc.m115.680470. CMCF-ID Health
Heald, Robert; Bowman, Krista K.; Bryan, Marian C.; Burdick, Daniel; Chan, Bryan et al. (2015). Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study. Journal of Medicinal Chemistry 58(22) , 8877-8895. 10.1021/acs.jmedchem.5b01412. [PDB: 5cal, 5cao, 5cap] CMCF-ID Health
Ndubaku, Chudi O.; Crawford, James J.; Drobnick, Joy; Aliagas, Ignacio; Campbell, David et al. (2015). Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pKa Polar Moiety. ACS Medicinal Chemistry Letters 6(12) , 1241-1246. 10.1021/acsmedchemlett.5b00398. CMCF-ID Health
Parker, Michelle L.; Penarete-Vargas, Diana M.; Hamilton, Phineas T.; Guérin, Amandine; Dubey, Jitender P. et al. (2015). Dissecting the interface between apicomplexan parasite and host cell: Insights from a divergent AMA–RON2 pair. Proceedings of the National Academy of Sciences of the United States of America 113(2) , 398-403. 10.1073/pnas.1515898113. [PDB: 4z80, 4z81] CMCF-ID Health
Raheem, Izzat T.; Walji, Abbas M.; Klein, Daniel; Sanders, John M.; Powell, David A. et al. (2015). Discovery of 2-Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV-1 Integrase Strand Transfer Inhibitors. Journal of Medicinal Chemistry 58(20) , 8154-8165. 10.1021/acs.jmedchem.5b01037. [PDB: 4ztf] CMCF-ID Health
Robb, Melissa; Robb, Craig S.; Higgins, Melanie A.; Hobbs, Joanne K.; Paton, James C. et al. (2015). A Second β-Hexosaminidase Encoded in the Streptococcus pneumoniae Genome Provides an Expanded Biochemical Ability to Degrade Host Glycans. Journal of Biological Chemistry 290(52) , 30888-30900. 10.1074/jbc.m115.688630. [PDB: 5a6a, 5a6b, 5a6k, 5ac5] CMCF-ID Health
Scapin, Giovanna; Yang, Xiaoyu; Prosise, Winifred W; McCoy, Mark; Reichert, Paul et al. (2015). Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab. Nature Structural and Molecular Biology 22(12) , 953-958. 10.1038/nsmb.3129. [PDB: 5dk3] CMCF-ID Health
Shin, Youngsook; Suchomel, Julia; Cardozo, Mario; Duquette, Jason; He, Xiao et al. (2015). Discovery, Optimization, and in Vivo Evaluation of Benzimidazole Derivatives AM-8508 and AM-9635 as Potent and Selective PI3Kδ Inhibitors. Journal of Medicinal Chemistry 59(1) , 431-447. 10.1021/acs.jmedchem.5b01651. [PDB: 5eds] CMCF-ID Health
Zhang, Qi; Fan, Lixin; Hou, Feng; Dong, Aiping; Wang, Yun-Xing et al. (2015). New Insights into the RNA-Binding and E3 Ubiquitin Ligase Activities of Roquins. Scientific Reports 5(1) . 10.1038/srep15660. [PDB: 4z30] CMCF-ID Health
Alaidi; Osama (2015). Structural characterization of Gemini-based nanoparticles for delivery of DNA. Supervisor: Grochulski, Pawel; Badea, Ildiko. Saskatchewan: University of Saskatchewan. CMCF-BM, CMCF-ID Health