Publication Beamlines Strategic Pillar
Xu, Shangyi; Grochulski, Pawel; Tanaka, Takuji (2024). Structural basis for the allosteric behaviour and substrate specificity of Lactococcus lactis Prolidase. Biochimica et Biophysica Acta - Proteins and Proteomics 1872(3) , 141000. 10.1016/j.bbapap.2024.141000. CMCF-BM, CMCF-ID Health
Shurtleff, Valerie W.; Layton, Mark E.; Parish, Craig A.; Perkins, James J.; Schreier, John D. et al. (2024). Invention of MK-7845, a SARS-CoV-2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic. Journal of Medicinal Chemistry . 10.1021/acs.jmedchem.3c02248. [PDB: 8ute] CMCF-BM Health
Puumala, Emily; Sychantha, David; Lach, Elizabeth; Reeves, Shawn; Nabeela, Sunna et al. (2024). Allosteric inhibition of tRNA synthetase Gln4 by N-pyrimidinyl-β-thiophenylacrylamides exerts highly selective antifungal activity. Cell Chemical Biology . 10.1016/j.chembiol.2024.01.010. [PDB: 8uk6] CMCF-ID Health
Pushie, M. Jake; Sylvain, Nicole J.; Hou, Huishu; George, Dominic; Kelly, Michael E. et al. (2024). Ion Dyshomeostasis in the Early Hyperacute Phase after a Temporary Large-Vessel Occlusion Stroke. ACS Chemical Neuroscience . 10.1021/acschemneuro.3c00685. MID-IR Health
Petraccione, Kaylee; Ali, Mohamed G. H.; Cyr, Normand; Wahba, Haytham M.; Stocker, Timothy et al. (2024). An LIR motif in the Rift Valley fever virus NSs protein is critical for the interaction with LC3 family members and inhibition of autophagy. PLoS Pathogens 20(3) , e1012093. 10.1371/journal.ppat.1012093. [PDB: 8t2m] CMCF-BM Health
Perez-Bermejo, Juan A.; Efagene, Oghene; Matern, William M.; Holden, Jeffrey K.; Kabir, Shaheen et al. (2024). Functional screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair. Nature Communications 15(1) . 10.1038/s41467-024-46816-5. [PDB: 8svg, 8svh, 8svi] CMCF-ID Health
Micuda, Ashley; Li, Hao; Rask‐Andersen, Helge; Ladak, Hanif M.; Agrawal, Sumit K. et al. (2024). Morphologic Analysis of the Scala Tympani Using Synchrotron: Implications for Cochlear Implantation. Laryngoscope . 10.1002/lary.31263. BMIT-ID Health
Li, Franco K. K.; Worrall, Liam J.; Gale, Robert T.; Brown, Eric D.; Strynadka, Natalie C. J. et al. (2024). Cryo-EM analysis of S. aureus TarL, a polymerase in wall teichoic acid biogenesis central to virulence and antibiotic resistance. Science advances 10(9) . 10.1126/sciadv.adj3864. [PDB: 8v33] CMCF-ID Health
Ketcham, John M.; Harwood, Stephen J.; Aranda, Ruth; Aloiau, Athenea N.; Bobek, Briana M. et al. (2024). Discovery of Pyridopyrimidinones that Selectively Inhibit the H1047R PI3Kα Mutant Protein. Journal of Medicinal Chemistry . 10.1021/acs.jmedchem.4c00078. [PDB: 8v8h] CMCF-ID Health
Kalugin, Denis; Bahig, Jumanah; Shoker, Ahmed; Doan, Huu; Kirychuk, Shelley et al. (2024). Superhydrophobic polyether sulfone (PES) dialysis membrane with enhanced hemocompatibility and reduced human serum protein interactions: Ex vivo, in situ synchrotron imaging, experimental, and computational studies. Separation and Purification Technology 335, 126071. 10.1016/j.seppur.2023.126071. BMIT-BM Health
Kaasalainen, Martti; Zhang, Ran; Vashisth, Priya; Birjandi, Anahid Ahmadi; S’Ari, Mark et al. (2024). Lithiated porous silicon nanowires stimulate periodontal regeneration. Nature Communications 15(1) . 10.1038/s41467-023-44581-5. VLS-PGM Health
He, Liqi; Zhang, Meng Yao; Cox, Matthew; Zhang, Qian; Donnell, Andrew F. et al. (2024). Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology. ACS Medicinal Chemistry Letters 15(2) , 189-196. 10.1021/acsmedchemlett.3c00456. [PDB: 8s9h] CMCF-ID Health
Giese, Dina; Li, Hao; Liu, Wei; Staxäng, Karin; Hodik, Monika et al. (2024). Microanatomy of the human tunnel of Corti structures and cochlear partition‐tonotopic variations and transcellular signaling. Journal of Anatomy . 10.1111/joa.14045. BMIT-ID Health
Folger, Ines B.; Frota, Natália F.; Pistofidis, Angelos; Niquille, David L.; Hansen, Douglas A. et al. (2024). High-throughput reprogramming of an NRPS condensation domain. Nature Chemical Biology . 10.1038/s41589-023-01532-x. [PDB: 8f7f] CMCF-ID Health
Daniel-Ivad, Phillip; Ryan, Katherine S. (2024). Structure of methyltransferase RedM that forms the dimethylpyrrolinium of the bisindole reductasporine. Journal of Biological Chemistry 300(1) , 105520. 10.1016/j.jbc.2023.105520. CMCF Health