Publication Beamlines Strategic Pillar
Akaki, Tatsuo; Bessho, Yuki; Ito, Takashi; Fujioka, Shingo; Ubukata, Minoru et al. (2021). Fragment-based lead discovery to identify novel inhibitors that target the ATP binding site of pyruvate dehydrogenase kinases. Bioorganic and Medicinal Chemistry 44, 116283. 10.1016/j.bmc.2021.116283. [PDB: 7ebb] CMCF-ID Health
Bai, Bing; Belovodskiy, Alexandr; Hena, Mostofa; Kandadai, Appan Srinivas; Joyce, Michael A. et al. (2021). Peptidomimetic α-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and in Vitro Biological Stability. Journal of Medicinal Chemistry 65(4) . 10.1021/acs.jmedchem.1c00616. CMCF-BM Health
Ereño-Orbea, June; Liu, Xianglei; Sicard, Taylor; Kucharska, Iga; Li, Wei et al. (2021). Structural details of monoclonal antibody m971 recognition of the membrane-proximal domain of CD22. Journal of Biological Chemistry 297(2) , 100966. 10.1016/j.jbc.2021.100966. [PDB: 7o4y, 7o52] CMCF-ID Health
Gavai, Ashvinikumar V.; Norris, Derek; Delucca, George; Tortolani, David; Tokarski, John S. et al. (2021). Discovery and Preclinical Pharmacology of an Oral Bromodomain and Extra-Terminal (BET) Inhibitor Using Scaffold-Hopping and Structure-Guided Drug Design. Journal of Medicinal Chemistry 64(19) . 10.1021/acs.jmedchem.1c00625. [PDB: 5s9r] CMCF-ID Health
Grochulski, Pawel; Labiuk, Shaunivan (2021). Review of health research at the Canadian Light Source. Nuclear Instruments and Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms 499, 70-76. 10.1016/j.nimb.2021.05.003. BIOXAS, BMIT, CMCF, MID-IR, SM, SXRMB, VESPERS Health
Jiang, Yingying; Tan, Shuo; Hu, Jianping; Chen, Xin; Chen, Feng et al. (2021). Amorphous calcium magnesium phosphate nanocomposites with superior osteogenic activity for bone regeneration. Regenerative Biomaterials 8(6) , rbab068. 10.1093/rb/rbab068. SXRMB Health
Kumar, Amit; Paul, Marilyn; Panda, Manoranjan; Jayaram, Shruthi; Kalidindi, Narasimharaju et al. (2021). Molecular mechanism of interspecies differences in the binding affinity of TD139 to Galectin-3. Glycobiology 31(10) . 10.1093/glycob/cwab072. [PDB: 7cxa] CMCF-ID Health
Mushtaha, Farah N.; Kuehn, Tristan K.; El‐Deeb, Omar; Rohani, Seyed A.; Helpard, Luke W. et al. (2021). Design and characterization of a 3D‐printed axon‐mimetic phantom for diffusion MRI. Magnetic Resonance in Medicine 86(5) , 2482–2496. 10.1002/mrm.28886. BMIT-ID Health
Radka, Christopher D.; Aller, Stephen G. (2021). Site 2 of the Yersinia pestis substrate-binding protein YfeA is a dynamic surface metal-binding site. Acta Crystallographica Section F:Structural Biology Communications 77(9) , 286-293. 10.1107/s2053230x21008086. [PDB: 7me1] CMCF-BM Health
Reid, Joel W.; Kaduk, James A. (2021). Crystal structure of donepezil hydrochloride form III, C24H29NO3⋅HCl. Powder Diffraction 36(4) , 233-240. 10.1017/s0885715621000415. Health
Rutbeek, Nicole R.; Rezasoltani, Hanieh; Patel, Trushar R.; Khajehpour, Mazdak; Prehna, Gerd et al. (2021). Molecular mechanism of quorum sensing inhibition in Streptococcus by the phage protein paratox. Journal of Biological Chemistry 297(3) , 100992. 10.1016/j.jbc.2021.100992. CMCF-ID Health
Schenkel, Laurie B.; Molina, Jennifer R.; Swinger, Kerren K.; Abo, Ryan; Blackwell, Danielle J. et al. (2021). A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explants. Cell Chemical Biology 28(8) . 10.1016/j.chembiol.2021.02.010. [PDB: 6we2] CMCF-ID Health
Schulte, Christie A.; Deaton, David N.; Diaz, Elsie; Do, Young; Gampe, Robert T. et al. (2021). A knowledge-based, structural-aided discovery of a novel class of 2-phenylimidazo[1,2-a]pyridine-6-carboxamide H-PGDS inhibitors. Bioorganic and Medicinal Chemistry Letters 47, 128113. 10.1016/j.bmcl.2021.128113. [PDB: 7jr6] CMCF-ID Health
Toplak, Marko; Read, Stuart T.; Sandt, Christophe; Borondics, Ferenc (2021). Quasar: Easy Machine Learning for Biospectroscopy. Cells 10(9) , 2300. 10.3390/cells10092300. MID-IR Health
Workman, Sean D.; Day, Jonathan; Farha, Maya A.; El Zahed, Sara S.; Bon, Chris et al. (2021). Structural Insights into the Inhibition of Undecaprenyl Pyrophosphate Synthase from Gram-Positive Bacteria. Journal of Medicinal Chemistry 64(18) , 13540–13550. 10.1021/acs.jmedchem.1c00941. [PDB: 7jli] CMCF-ID Health